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ALGOSB 2020 - Intrinsic Disorder in Proteins : From non-Folding to Fuzzy Recognition to Phase Separation

Organized by C. Robert

AlgoSB 2020 is devoted to the problem of Intrinsically Disordered Proteins (IDPs) as well as proteins having structurally disordered regions (IDRs). Until recently, structural biologists have for the most part focused on proteins whose polypeptide chain assumed a well-defined, "folded" 3D structure in terms of the x, y, and z coordinates of each atom in the molecule. This is understandable, as continual improvements in X-ray crystallography and electron microscopy have resulted in the 3D structures of an enormous number of proteins, which are deposited into public databases and studied extensively. It became clear, however, that a separate class of proteins, while essential to the organism, did not seem to fold to a native structure— on the contrary they required a marked degree of conformational heterogeneity in order to function. These proteins are sometimes characterized as the "dark matter" of the cell.

DONZELLA DOMINIQUE | Mise à jour le 04/03/2020
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Du lundi 23 novembre 2020 à 09h00 au vendredi 27 novembre 2020 à 17h00

Institut d'Etudes Scientifiques, Cargèse, Cargèse